The plasma membrane of eukaryotic cells is not a simple sheet of lipids and proteins but is
differentiated into subdomains with crucial functions. Caveolae, small pits in the plasma …

Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …

Abstract The methyltransferase like 3 (METTL3) has been generally recognized as a nuclear
protein bearing oncogenic properties. We find predominantly cytoplasmic METTL3 …

Endocytic mechanisms control the lipid and protein composition of the plasma membrane,
thereby regulating how cells interact with their environments. Here, we review what is known …

The interactions between cancer cells and their micro-and macroenvironment create a
context that promotes tumour growth and protects it from immune attack. The functional …

Caveolae are a highly abundant but enigmatic feature of mammalian cells. They form
remarkably stable membrane domains at the plasma membrane but can also function as …

Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and
endothelia. Recently, we have shown that the human CAV-1 gene is localized to a …

Although they were discovered more than 50 years ago, caveolae have remained enigmatic
plasmalemmal organelles. With their characteristic “flasklike” shape and virtually ubiquitous …

Loss of stromal fibroblast caveolin-1 (Cav-1) is a powerful single independent predictor of
poor prognosis in human breast cancer patients, and is associated with early tumor …

Considerable evidence now implicates elevated expression and/or activity of Src in cancer
development. In cells, endogenous Src is switched from an inactive to an active state by a …