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Brain energy and oxygen metabolism: emerging role in normal function and disease
Dynamic metabolic changes occurring in neurons are critically important in directing brain
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …
plasticity and cognitive function. In other tissue types, disruptions to metabolism and the …
[HTML][HTML] α-Synuclein misfolding and Parkinson's disease
Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …
The Lewy body in Parkinson's disease and related neurodegenerative disorders
The histopathological hallmark of Parkinson's disease (PD) is the presence of fibrillar
aggregates referred to as Lewy bodies (LBs), in which α-synuclein is a major constituent …
aggregates referred to as Lewy bodies (LBs), in which α-synuclein is a major constituent …
Therapeutics in the pipeline targeting α-synuclein for Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder and the
fastest growing neurologic disease in the world, yet no disease-modifying therapy is …
fastest growing neurologic disease in the world, yet no disease-modifying therapy is …
Repression of α-synuclein expression and toxicity by microRNA-7
α-Synuclein is a key protein in Parkinson's disease (PD) because it accumulates as fibrillar
aggregates in pathologic hallmark features in affected brain regions, most notably in nigral …
aggregates in pathologic hallmark features in affected brain regions, most notably in nigral …
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases
M Trapecar, E Wogram, D Svoboda, C Communal… - Science …, 2021 - science.org
Slow progress in the fight against neurodegenerative diseases (NDs) motivates an urgent
need for highly controlled in vitro systems to investigate organ-organ–and organ-immune …
need for highly controlled in vitro systems to investigate organ-organ–and organ-immune …
The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of α‐synuclein aggregates
The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates
called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal …
called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal …
Neuropathology, biochemistry, and biophysics of α‐synuclein aggregation
Aggregation of α‐synuclein, an abundant and conserved pre‐synaptic brain protein, is
implicated as a critical factor in several neurodegenerative diseases. These diseases …
implicated as a critical factor in several neurodegenerative diseases. These diseases …
[HTML][HTML] Role of transglutaminase 2 in cell death, survival, and fibrosis
Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme catalyzing the crosslinking
between Gln and Lys residues and involved in various pathophysiological events. Besides …
between Gln and Lys residues and involved in various pathophysiological events. Besides …
Hsp70 reduces α-synuclein aggregation and toxicity
Aggregation and cytotoxicity of misfolded α-synuclein is postulated to be crucial in the
disease process of neurodegenerative disorders such as Parkinson's disease and DLB …
disease process of neurodegenerative disorders such as Parkinson's disease and DLB …