The MiT‐TFE family of basic helix‐loop‐helix leucine‐zipper transcription factors includes
four members: TFEB, TFE 3, TFEC, and MITF. Originally described as oncogenes, these …

Investigations of patients with systemic lupus erythematosus have applied insights from
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …

Abstract Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against
infections and cancer, but excessive IRF3 activation and type I IFN production cause …

STING is an ER-associated membrane protein that is critical for innate immune sensing of
pathogens. STING-mediated activation of the IFN-I pathway through the TBK1/IRF3 …

Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic
acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated …

In recent years, our vision of lysosomes has drastically changed. Formerly considered to be
mere degradative compartments, they are now recognized as key players in many cellular …

Summary Background Aicardi-Goutières syndrome (AGS) is an inflammatory disorder
caused by mutations in any of six genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C …

The activation of transcription factors is critical to ensure an effective defense against
pathogens. In this study we identify a critical and complementary role of the transcription …

Replication of lentiviruses generates different DNA forms, including RNA: DNA hybrids,
ssDNA, and dsDNA. Nucleic acids stimulate innate immune responses, and pattern …

Hypomorphic mutations in the DNA repair enzyme RNase H2 cause the neuroinflammatory
autoimmune disorder Aicardi-Goutières syndrome (AGS). Endogenous nucleic acids are …