Monocyte chemoattractant protein-1 (MCP-1): an overview

SL Deshmane, S Kremlev, S Amini… - Journal of interferon & …, 2009 - liebertpub.com
Chemokines constitute a family of chemoattractant cytokines and are subdivided into four
families on the basis of the number and spacing of the conserved cysteine residues in the N …

Targeting CCL5 in inflammation

RE Marques, R Guabiraba, RC Russo… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Chemokines play important roles in inflammation and in immune responses.
This article will discuss the current literature on the C–C chemokine ligand 5 (CCL5), and …

Conventional and monocyte-derived CD11b+ dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen

M Plantinga, M Guilliams, M Vanheerswynghels… - Immunity, 2013 - cell.com
Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear
which subset of DCs performs this task. By using CD64 and MAR-1 staining, we reliably …

The eosinophil

ME Rothenberg, SP Hogan - Annu. Rev. Immunol., 2006 - annualreviews.org
Eosinophils have been considered end-stage cells involved in host protection against
parasites. However, numerous lines of evidence have now changed this perspective by …

Role of CCL2/CCR2 axis in the pathogenesis of COVID-19 and possible Treatments: All options on the Table

M Ranjbar, A Rahimi, Z Baghernejadan… - International …, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is cause of the novel
coronavirus disease (COVID-19). In the last two years, SARS-CoV-2 has infected millions of …

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

Z Zhu, RJ Homer, Z Wang, Q Chen, GP Geba… - The Journal of clinical …, 1999 - jci.org
Interleukin (IL)-13 is a pleiotropic cytokine produced in large quantities by activated CD4+
Th2 lymphocytes. To define further its potential in vivo effector functions, the Clara cell 10 …

Monocyte-mediated defense against microbial pathogens

NV Serbina, T Jia, TM Hohl, EG Pamer - Annu. Rev. Immunol., 2008 - annualreviews.org
Circulating blood monocytes supply peripheral tissues with macrophage and dendritic cell
(DC) precursors and, in the setting of infection, also contribute directly to immune defense …

T-cell function and migration—two sides of the same coin

UH Von Andrian, CR Mackay - New England Journal of Medicine, 2000 - Mass Medical Soc
Since the pioneering work of Gowans and colleagues in the 1960s, 1, 2 much progress has
been made in understanding the pivotal role of cell migration in immunity. We now have …

Chemokines and disease

C Gerard, BJ Rollins - Nature immunology, 2001 - nature.com
We examine here several diseases that are associated with inappropriate activation of the
chemokine network. Detailed comment has been restricted to pathological states for which …

Eosinophils: biological properties and role in health and disease

SP Hogan, HF Rosenberg, R Moqbel… - Clinical & …, 2008 - Wiley Online Library
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …