The p53 protein regulates the transcription of many different genes in response to a wide
variety of stress signals. Following DNA damage, p53 regulates key processes, including …

Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function
(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal …

The ability of~ 53 to activate transcription from specific sequences suggests that genes
induced by p53 may mediate its biological role as a tumor suppressor. Using a subtractive …

Background: The p53 tumor suppressor gene is mutated in a large percentage of human
malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit …

The p53 protein can bind to a set of specific DNA sequences, and this may activate the
transcription of genes adjacent to these DNA elements. The mdm-2 gene is shown here to …

Tumorigenesis is associated with enhanced cellular glucose uptake and increased
metabolism. Because the p53 tumor suppressor is mutated in a large number of cancers, we …

Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …

As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of
the critical and complex roles played by p53 is progressing rapidly, new findings continue to …

Abstract Full-length p53 (p53α) plays a pivotal role in maintaining genomic integrity and
preventing tumor development. Over the years, p53 was found to exist in various isoforms …

Abnormalities of the p53 tumour suppressor gene are among the most frequent molecular
events in human and animal neoplasia. Moreover, p53 is one of the most studied proteins in …