The developmental origins of adult disease (Barker) hypothesis

HA De Boo, JE Harding - Australian and New Zealand Journal …, 2006 - Wiley Online Library
Many studies have provided evidence for the hypothesis that size at birth is related to the
risk of develo** disease in later life. In particular, links are well established between …

Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease

KM Godfrey, KA Lillycrop, GC Burdge, PD Gluckman… - Pediatric …, 2007 - nature.com
There is now considerable evidence that elements of the heritable or familial component of
disease susceptibility are transmitted by nongenomic means, and that environmental …

Developmental programming, a pathway to disease

V Padmanabhan, RC Cardoso… - Endocrinology, 2016 - academic.oup.com
Accumulating evidence suggests that insults occurring during the perinatal period alter the
developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes …

Effects of maternal nutrition on conceptus growth and offspring performance: implications for beef cattle production

RN Funston, DM Larson… - Journal of animal …, 2010 - academic.oup.com
Developmental programming is the concept that a maternal stimulus or insult at a critical
period in fetal development has long-term effects on the offspring. Historically, considerable …

Does skeletal muscle have an 'epi'‐memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise

AP Sharples, CE Stewart, RA Seaborne - Aging cell, 2016 - Wiley Online Library
Skeletal muscle mass, quality and adaptability are fundamental in promoting muscle
performance, maintaining metabolic function and supporting longevity and healthspan …

Nutritional programming of the metabolic syndrome

ME Symonds, SP Sebert, MA Hyatt… - Nature Reviews …, 2009 - nature.com
The primary markers of the metabolic syndrome are central obesity, insulin resistance and
hypertension. In this review, we consider the effect of changes in maternal nutrition during …

The clinical importance of nephron mass

VA Luyckx, BM Brenner - Journal of the American Society of …, 2010 - journals.lww.com
Abundant evidence supports the association between low birth weight (LBW) and renal
dysfunction in humans. Anatomic measurements of infants, children, and adults show …

Maternal undernutrition during early to mid-gestation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring

SP Ford, BW Hess, MM Schwope… - Journal of animal …, 2007 - academic.oup.com
This study utilized maternal undernutrition from early to midgestation in the ewe to determine
the impact (s) of intrauterine growth restriction on postpartum growth of male offspring and …

Factors affecting birth weight in sheep: maternal environment

DS Gardner, PJ Buttery, Z Daniel… - Reproduction, 2007 - rep.bioscientifica.com
Knowledge of factors affecting variation in birth weight is especially important given the
relationship of birth weight to neonatal and adult health. The present study utilises two large …

Developmental origins of adult disease

SC Langley-Evans, S McMullen - Medical principles and practice, 2010 - karger.com
Variation in the quality or quantity of nutrients consumed during pregnancy can exert
permanent and powerful effects upon the develo** fetus. This programming of fetal …