Toxin–antitoxin systems and their role in disseminating and maintaining antimicrobial resistance

QE Yang, TR Walsh - FEMS microbiology reviews, 2017 - academic.oup.com
Toxin–antitoxin systems (TAs) are ubiquitous among bacteria and play a crucial role in the
dissemination and evolution of antibiotic resistance, such as maintaining multi-resistant …

Kee** the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems

WT Chan, M Espinosa, CC Yeo - Frontiers in molecular biosciences, 2016 - frontiersin.org
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to
bacterial plasmids where they function to mediate the maintenance and stability of usually …

RETRACTED: Stochastic induction of persister cells by HipA through (p) ppGpp-mediated activation of mRNA endonucleases

E Germain, M Roghanian, K Gerdes… - Proceedings of the …, 2015 - pnas.org
The model organism Escherichia coli codes for at least 11 type II toxin–antitoxin (TA)
modules, all implicated in bacterial persistence (multidrug tolerance). Ten of these encode …

Phenotypic heterogeneity, a phenomenon that may explain why quorum sensing does not always result in truly homogenous cell behavior

J Grote, D Krysciak, WR Streit - Applied and environmental …, 2015 - Am Soc Microbiol
Phenotypic heterogeneity describes the occurrence of “nonconformist” cells within an
isogenic population. The nonconformists show an expression profile partially different from …

Type II bacterial toxin–antitoxins: hypotheses, facts, and the newfound plethora of the PezAT system

WT Chan, MP Garcillán-Barcia, CC Yeo… - FEMS Microbiology …, 2023 - academic.oup.com
Toxin–antitoxin (TA) systems are entities found in the prokaryotic genomes, with eight
reported types. Type II, the best characterized, is comprised of two genes organized as an …

Immune response modulation by Pseudomonas aeruginosa persister cells

CJ Hastings, GE Himmler, A Patel, CNH Marques - Mbio, 2023 - Am Soc Microbiol
Bacterial persister cells—a metabolically dormant subpopulation tolerant to antimicrobials—
contribute to chronic infections and are thought to evade host immunity. In this work, we …

The variety in the common theme of translation inhibition by type II toxin–antitoxin systems

D Jurėnas, L Van Melderen - Frontiers in genetics, 2020 - frontiersin.org
Type II Toxin–antitoxin (TA) modules are bacterial operons that encode a toxic protein and
its antidote, which form a self-regulating genetic system. Antitoxins put a halter on toxins in …

Biosorption of Sr2+ and Cs+ onto Undaria pinnatifida: Isothermal titration calorimetry and molecular dynamics simulation

Y Hu, X Guo, J Wang - Journal of Molecular Liquids, 2020 - Elsevier
In this paper, the biosorption of strontium and cesium ions onto a marine brown alga
Undaria pinnatifida (also known as wakame), was studied using isothermal titration …

Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila

X Zhen, Y Wu, J Ge, J Fu, L Ye, N Lin, Z Huang… - Nature …, 2022 - nature.com
Toxin-antitoxin (TA) systems are ubiquitous genetic modules in bacteria and archaea. Here,
we perform structural and biochemical characterization of the Legionella pneumophila …

A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT

A Talavera, H Tamman, A Ainelo… - Nature …, 2019 - nature.com
Bacterial toxin-antitoxin (TA) modules are tightly regulated to maintain growth in favorable
conditions or growth arrest during stress. A typical regulatory strategy involves the antitoxin …