Toxin–antitoxin systems and their role in disseminating and maintaining antimicrobial resistance
QE Yang, TR Walsh - FEMS microbiology reviews, 2017 - academic.oup.com
Toxin–antitoxin systems (TAs) are ubiquitous among bacteria and play a crucial role in the
dissemination and evolution of antibiotic resistance, such as maintaining multi-resistant …
dissemination and evolution of antibiotic resistance, such as maintaining multi-resistant …
Kee** the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to
bacterial plasmids where they function to mediate the maintenance and stability of usually …
bacterial plasmids where they function to mediate the maintenance and stability of usually …
RETRACTED: Stochastic induction of persister cells by HipA through (p) ppGpp-mediated activation of mRNA endonucleases
E Germain, M Roghanian, K Gerdes… - Proceedings of the …, 2015 - pnas.org
The model organism Escherichia coli codes for at least 11 type II toxin–antitoxin (TA)
modules, all implicated in bacterial persistence (multidrug tolerance). Ten of these encode …
modules, all implicated in bacterial persistence (multidrug tolerance). Ten of these encode …
Phenotypic heterogeneity, a phenomenon that may explain why quorum sensing does not always result in truly homogenous cell behavior
J Grote, D Krysciak, WR Streit - Applied and environmental …, 2015 - Am Soc Microbiol
Phenotypic heterogeneity describes the occurrence of “nonconformist” cells within an
isogenic population. The nonconformists show an expression profile partially different from …
isogenic population. The nonconformists show an expression profile partially different from …
Type II bacterial toxin–antitoxins: hypotheses, facts, and the newfound plethora of the PezAT system
Toxin–antitoxin (TA) systems are entities found in the prokaryotic genomes, with eight
reported types. Type II, the best characterized, is comprised of two genes organized as an …
reported types. Type II, the best characterized, is comprised of two genes organized as an …
Immune response modulation by Pseudomonas aeruginosa persister cells
Bacterial persister cells—a metabolically dormant subpopulation tolerant to antimicrobials—
contribute to chronic infections and are thought to evade host immunity. In this work, we …
contribute to chronic infections and are thought to evade host immunity. In this work, we …
The variety in the common theme of translation inhibition by type II toxin–antitoxin systems
Type II Toxin–antitoxin (TA) modules are bacterial operons that encode a toxic protein and
its antidote, which form a self-regulating genetic system. Antitoxins put a halter on toxins in …
its antidote, which form a self-regulating genetic system. Antitoxins put a halter on toxins in …
Biosorption of Sr2+ and Cs+ onto Undaria pinnatifida: Isothermal titration calorimetry and molecular dynamics simulation
Y Hu, X Guo, J Wang - Journal of Molecular Liquids, 2020 - Elsevier
In this paper, the biosorption of strontium and cesium ions onto a marine brown alga
Undaria pinnatifida (also known as wakame), was studied using isothermal titration …
Undaria pinnatifida (also known as wakame), was studied using isothermal titration …
Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila
X Zhen, Y Wu, J Ge, J Fu, L Ye, N Lin, Z Huang… - Nature …, 2022 - nature.com
Toxin-antitoxin (TA) systems are ubiquitous genetic modules in bacteria and archaea. Here,
we perform structural and biochemical characterization of the Legionella pneumophila …
we perform structural and biochemical characterization of the Legionella pneumophila …
A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT
Bacterial toxin-antitoxin (TA) modules are tightly regulated to maintain growth in favorable
conditions or growth arrest during stress. A typical regulatory strategy involves the antitoxin …
conditions or growth arrest during stress. A typical regulatory strategy involves the antitoxin …