Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases
JH Viles - Coordination Chemistry Reviews, 2012 - Elsevier
There are a group of diseases associated with protein misfolding and accumulation into
amyloid fibers. Many of these diseases have a major impact on human health, in particular …
amyloid fibers. Many of these diseases have a major impact on human health, in particular …
Coordinating properties of peptides containing histidyl residues
Numerous studies have demonstrated the high metal binding capacity and selectivity of
peptide molecules. The terminal amino group, deprotonated amide nitrogens, and various …
peptide molecules. The terminal amino group, deprotonated amide nitrogens, and various …
Site-specific interactions of Cu (II) with α and β-synuclein: Bridging the molecular gap between metal binding and aggregation
The aggregation of α-synuclein (AS) is a critical step in the etiology of Parkinson's disease
(PD) and other neurodegenerative synucleinopathies. Protein− metal interactions play a …
(PD) and other neurodegenerative synucleinopathies. Protein− metal interactions play a …
Structural characterization of Cu2+, Ni2+ and Zn2+ binding sites of model peptides associated with neurodegenerative diseases
C Migliorini, E Porciatti, M Luczkowski… - Coordination Chemistry …, 2012 - Elsevier
Metal ions, especially redox active copper, are thought to play critical roles in
neurodegenerative disorders. As a matter of fact, metal binding may result into severe …
neurodegenerative disorders. As a matter of fact, metal binding may result into severe …
Methods and techniques to study the bioinorganic chemistry of metal–peptide complexes linked to neurodegenerative diseases
This article provides a review about the most common techniques used to study the
interaction of metal ions with amyloidogenic peptides. It is addressed to researchers, who …
interaction of metal ions with amyloidogenic peptides. It is addressed to researchers, who …
Specific metal ion binding sites in unstructured regions of proteins
In this review, we summarize the most recent observations on some very effective binding
sites (eg ATCUN motif, poly-His, poly-Cys, or Met-containing sequences) for biologically …
sites (eg ATCUN motif, poly-His, poly-Cys, or Met-containing sequences) for biologically …
Copper (II)-induced secondary structure changes and reduced folding stability of the prion protein
The cellular isoform of the prion protein PrP C is a Cu 2+-binding cell surface glycoprotein
that, when misfolded, is responsible for a range of transmissible spongiform …
that, when misfolded, is responsible for a range of transmissible spongiform …
Histidine tracts in human transcription factors: insight into metal ion coordination ability
A Hecel, J Wątły, M Rowińska-Żyrek… - JBIC Journal of …, 2018 - Springer
Consecutive histidine repeats are chosen both by nature and by molecular biologists due to
their high affinity towards metal ions. Screening of the human genome showed that …
their high affinity towards metal ions. Screening of the human genome showed that …
Biophysical approaches for the study of metal-protein interactions
D Witkowska, M Rowińska-Żyrek - Journal of Inorganic Biochemistry, 2019 - Elsevier
Protein-protein interactions play important roles for a variety of cell functions, often involving
metal ions; in fact, metal-ion binding mediates and regulates the activity of a wide range of …
metal ions; in fact, metal-ion binding mediates and regulates the activity of a wide range of …
Prion proteins and copper ions. Biological and chemical controversies
The Prion protein (PrPc) involvement in some neurodegenerative diseases is well assessed
although its “normal” biological role is not completely understood. It is known that PrPC can …
although its “normal” biological role is not completely understood. It is known that PrPC can …