The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4
have critical roles in skeletal muscle development. Together with the Mef2 proteins and E …

Hox genes encode homeodomain-containing transcription factors that pattern the body axes
of animal embryos. It is well established that the exquisite DNA-binding specificity that …

Abstract Pachytene PIWI-interacting RNAs (piRNAs), which comprise> 80% of small RNAs
in the adult mouse testis, have been proposed to bind and regulate target RNAs like …

Oncogenic mutations of the MLL histone methyltransferase confer an unusual ability to
transform non-self-renewing myeloid progenitors into leukemia stem cells (LSCs) by …

TALE (three amino acids loop extension) homeodomain transcription factors are required in
various steps of embryo development, in many adult physiological functions, and are …

Morphogenesis of mammalian facial processes requires coordination of cellular
proliferation, migration, and apoptosis to develop intricate features. Cleft lip and/or palate …

Vertebrate limb development occurs along three cardinal axes–proximodistal,
anteroposterior and dorsoventral–that are established via the organization of signaling …

The identification of Hox genes as HSC regulators has been exploited to develop strategies
to efficiently expand HSCs ex vivo, a key step to the success of therapies based on HSC …

Congenital heart diseases are traditionally considered to be multifactorial in pathogenesis
resulting from environmental and genetic interactions that determine penetrance and …

Summary The interactions of Meis, Prep, and Pbx1 TALE homeoproteins with Hox proteins
are essential for development and disease. Although Meis and Prep behave similarly in …