Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Enterobacter aerogenes and E. cloacae have been reported as important opportunistic and
multiresistant bacterial pathogens for humans during the last three decades in hospital …

Most small molecules are unable to rapidly traverse the outer membrane of Gram-negative
bacteria and accumulate inside these cells, making the discovery of much-needed drugs …

Collective antibiotic drug resistance is a global threat, especially with respect to Gram-
negative bacteria. The low permeability of the bacterial outer cell wall has been identified as …

Gram-negative bacteria can resist antibiotics by changing the permeability via their outer
membrane. These bacteria have a complex cell envelope that incorporates an outer …

The structure of OmpF porin in complex with three common antibiotics (zwitterionic
ampicillin, anionic ertapenem, and di-anionic carbenicillin) was determined using X-ray …

Antibiotic-resistant bacteria, particularly Gram negative species, present significant health
care challenges. The permeation of antibiotics through the outer membrane is largely …

In the present work, we delineate the molecular mechanism of a bulky antibiotic permeating
through a bacterial channel and uncover the role of conformational dynamics of the …

The fitness cost of antibiotic resistance is a key parameter in determining the evolutionary
success of resistant bacteria. Studies of the effect of antibiotic resistance on bacterial fitness …

Bacterial resistance to the antibiotics develops rapidly and is increasingly serious health
concern in the world. It is an insoluble topic due to the multiple resistant mechanisms. The …