Organisms evolve in response to their natural environment. Consideration of natural
ecological parameters are thus of key importance for our understanding of an organism's …

Argonaute (AGO) proteins associate with small RNAs to direct their effector function on
complementary transcripts. The nematode Caenorhabditis elegans contains an expanded …

Animal host defense against infection requires the expression of defense genes at the right
place and the right time. Understanding such tight control of host defense requires the …

Abstract Background The nematode Caenorhabditis elegans is a major model organism in
laboratory biology. Very little is known, however, about its ecology, including where it …

Background Over the last ten years, there has been explosive development in methods for
measuring gene expression. These methods can identify thousands of genes altered …

Microsporidia comprise a phylum of over 1400 species of obligate intracellular pathogens
that can infect almost all animals, but little is known about the host response to these …

Host genetic landscapes can shape microbiome assembly in the animal gut by contributing
to the establishment of distinct physiological environments. However, the genetic …

Intestinal epithelial cells provide an essential line of defense for Caernohabditis elegans
against ingested pathogens. Because nematodes consume microorganisms as their food …

TFEB and TFE3 are transcriptional regulators of the innate immune response, but the
mechanisms regulating their activation upon pathogen infection are poorly elucidated. Using …

The maintenance of cellular and organismal homeostasis in the face of changes in the
environment is essential for survival. Pathogenic microorganisms represent one type of …