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Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
GPX4 in cell death, autophagy, and disease
ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases
Y Yu, Y Yan, F Niu, Y Wang, X Chen, G Su, Y Liu… - Cell death …, 2021 - nature.com
Ferroptosis, a recently identified and iron-dependent cell death, differs from other cell death
such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form …
such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form …
Molecular mechanisms of ferroptosis and relevance to inflammation
L Deng, S He, N Guo, W Tian, W Zhang, L Luo - Inflammation Research, 2023 - Springer
Introduction Inflammation is a defensive response of the organism to irritation which is
manifested by redness, swelling, heat, pain and dysfunction. The inflammatory response …
manifested by redness, swelling, heat, pain and dysfunction. The inflammatory response …
Forsythoside A mitigates Alzheimer's-like pathology by inhibiting ferroptosis-mediated neuroinflammation via Nrf2/GPX4 axis activation
C Wang, S Chen, H Guo, H Jiang, H Liu… - … journal of biological …, 2022 - pmc.ncbi.nlm.nih.gov
Ferroptosis and neuroinflammation play crucial roles in Alzheimer's disease (AD)
pathophysiology. Forsythoside A (FA), the main constituent of Forsythia suspensa (Thunb.) …
pathophysiology. Forsythoside A (FA), the main constituent of Forsythia suspensa (Thunb.) …
Role of glutathione in cancer: from mechanisms to therapies
Glutathione (GSH) is the most abundant non-protein thiol present at millimolar
concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a …
concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a …
Ferroptosis: past, present and future
J Li, F Cao, H Yin, Z Huang, Z Lin, N Mao, B Sun… - Cell death & …, 2020 - nature.com
Ferroptosis is a new type of cell death that was discovered in recent years and is usually
accompanied by a large amount of iron accumulation and lipid peroxidation during the cell …
accompanied by a large amount of iron accumulation and lipid peroxidation during the cell …
[HTML][HTML] The emerging role of ferroptosis in inflammation
Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid
peroxidation that is morphologically, biologically and genetically distinct from other types of …
peroxidation that is morphologically, biologically and genetically distinct from other types of …
Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging
D Lapenna - Ageing research reviews, 2023 - Elsevier
The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …
Ferroptosis: emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation
X **, J Tang, X Qiu, X Nie, S Ou, G Wu, R Zhang… - Cell Death …, 2024 - nature.com
Ferroptosis represents a distinct form of programmed cell death triggered by excessive iron
accumulation and lipid peroxidation-induced damage. This mode of cell death differentiates …
accumulation and lipid peroxidation-induced damage. This mode of cell death differentiates …