Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

Biological functions and current advances in isolation and detection strategies for exosome nanovesicles

K Boriachek, MN Islam, A Möller, C Salomon… - Small, 2018 - Wiley Online Library
Abstract Exosomes are nanoscale (≈ 30–150 nm) extracellular vesicles of endocytic origin
that are shed by most types of cells and circulate in bodily fluids. Exosomes carry a specific …

Microfluidic‐based exosome analysis for liquid biopsy

B Lin, Y Lei, J Wang, L Zhu, Y Wu, H Zhang… - Small …, 2021 - Wiley Online Library
Liquid biopsy offers non‐invasive and real‐time molecular profiling of individual patients,
and is thus considered a revolutionary technology in precision medicine. Exosomes have …

Early human trophoblast development: from morphology to function

M Gauster, G Moser, S Wernitznig, N Kupper… - Cellular and Molecular …, 2022 - Springer
Human pregnancy depends on the proper development of the embryo prior to implantation
and the implantation of the embryo into the uterine wall. During the pre-implantation phase …

Extracellular vesicles in obesity and diabetes mellitus

F Pardo, R Villalobos-Labra, B Sobrevia… - Molecular aspects of …, 2018 - Elsevier
Cell-to-cell communication happens via diverse mechanisms including the synthesis,
release and transfer to target cells of extracellular vesicles (EVs). EVs include nanovesicles …

Extracellular vesicle mediated embryo-endometrial cross talk during implantation and in pregnancy

NK Kurian, D Modi - Journal of assisted reproduction and genetics, 2019 - Springer
Extracellular vesicles are lipoproteinaceous membrane-enclosed nanometer-sized
structures produced by cells and are thought to mediate cellular communications. Loaded …

Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity

S Nair, N Jayabalan, D Guanzon, C Palma… - Clinical …, 2018 - portlandpress.com
There is increasing evidence that miRNAs, which are enriched in nanovesicles called
exosomes, are important regulators of gene expression. When compared with normal …

Regulation of maternal–fetal metabolic communication

CE Bowman, Z Arany, MJ Wolfgang - Cellular and molecular life sciences, 2021 - Springer
Pregnancy may be the most nutritionally sensitive stage in the life cycle, and improved
metabolic health during gestation and early postnatal life can reduce the risk of chronic …

Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction-Liquid biopsies to monitoring fetal growth

J Miranda, C Paules, S Nair, A Lai, C Palma… - Placenta, 2018 - Elsevier
Introduction Placenta-derived exosomes may represent an additional pathway by which the
placenta communicates with the maternal system to induce maternal vascular adaptations to …