Abstract The Pumilio (Pum)/Puf family proteins are ubiquitously present across eukaryotes,
including yeast, plants and humans. They generally bind to the 3′ untranslated regions of …

Translational control regulates the levels of protein synthesized from its transcript and is key
for the rapid adjustment of gene expression in response to environmental stimuli. The …

Mutations in the Plasmodium falciparum Kelch 13 (PfK13) protein are associated with
artemisinin resistance. PfK13 is essential for asexual erythrocytic development, but its …

Inflammatory cytokines are key signaling molecules that can promote an immune response,
thus their RNA turnover must be tightly controlled during infection. Most studies investigate …

The Protein Phosphatase type 1 catalytic subunit (PP1c)(PF3D7_1414400) operates in
combination with various regulatory proteins to specifically direct and control its …

Ribosomes, in general, are viewed as constitutive macromolecular machines where protein
synthesis takes place; however, this view has been recently challenged, supporting the …

Background Eukaryotic gene expression is controlled by a number of RNA-binding proteins
(RBP), such as the proteins from the Puf (Pumilio and FBF) superfamily (PufSF). These …

Malaria remains one of the most perilous vector-borne infectious diseases for humans
globally. Sexual gametocyte represents the exclusive stage at which malaria parasites are …

In eukaryotes, translation is a fundamental step in the long pathway of protein synthesis
within the cell. In this process, several proteins and factors have involved directly or …

Pumilio3 (Pum3), an evolutionarily distant homologue of the classical RNA-binding protein
PUF (PUMILIO and FBF) family member, is also involved in the process of RNA metabolism …