The aging of mammals is accompanied by the progressive atrophy of tissues and organs
and the accumulation of random damage to macromolecular DNA, protein, and lipids …

Membrane contact sites between organelles are essential for maintaining cellular
homeostasis, which requires the continuous exchange of signaling molecules, ions …

Accelerated biological aging, which involves the gradual decline of organ or tissue functions
and the distortion of physiological processes, underlies several human diseases. Away from …

The endoplasmic reticulum (ER) is the place where proteins and lipids are biosynthesized
and where transmembrane proteins are folded. Both pathological and physiological …

Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Hypertension is the leading remediable risk factor for cardiovascular morbidity and mortality
in the United States. Excess dietary salt consumption, which is a catalyst of hypertension …

Aging is an inevitable process influenced by genetics, lifestyles, and environments. With the
rapid social and economic development in recent decades, the proportion of the elderly has …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two major
neurodegenerative diseases. FTD is the second most common cause of dementia and ALS …

Plant secondary metabolites (PSMs) are a diverse group of bioactive compounds, including
flavonoids, polyphenols, saponins, and terpenoids, which have been recognised for their …

Alzheimer's disease (AD) is the most common neurodegenerative disease affecting a
growing number of elderly individuals. No disease-modifying drugs have yet been identified …