[HTML][HTML] Schwann cell functions in peripheral nerve development and repair

M Bosch-Queralt, R Fledrich, RM Stassart - Neurobiology of Disease, 2023 - Elsevier
The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

How the bone microenvironment shapes the pre-metastatic niche and metastasis

KN Jackett, AT Browne, ER Aber, M Clements… - Nature Cancer, 2024 - nature.com
The bone is a frequent metastatic site, with changes in the mineralized bone and the bone
marrow milieu that can also prime other sites for metastasis by educating progenitor cells to …

[HTML][HTML] Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration

P Yang, Y Peng, X Dai, J Jie, D Kong, X Gu, Y Yang - Bioactive materials, 2023 - Elsevier
Tissue regeneration requires exogenous and endogenous signals, and there is increasing
evidence that the exogenous microenvironment may play an even more dominant role in the …

Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment

M Xue, Y Zhu, Y Jiang, L Han, M Shi, R Su… - Nature …, 2023 - nature.com
Neuropathy is a feature more frequently observed in pancreatic ductal adenocarcinoma
(PDAC) than other tumors. Schwann cells, the most prevalent cell type in peripheral nerves …

Schwann cells in pancreatic cancer: Unraveling their multifaceted roles in tumorigenesis and neural interactions

Z Cai, H Yao, J Chen, AA Ahmed, C Li, X Hu, X Tang… - Cancer letters, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC), characterized by heightened neural density,
presents a challenging prognosis primarily due to perineural invasion. Recognized for their …

TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits

N Zhang, Q Ji, Y Chen, X Wen, F Shan - Cell Death & Disease, 2024 - nature.com
Triggering receptor expressed on myeloid cells-2 (TREM2) has been implicated in
susceptibility to neurodegenerative disease. Schwann cells (SCs), the predominant glial cell …

Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma

TK Olsen, J Otte, S Mei, BT Embaie, P Kameneva… - Molecular Cancer, 2024 - Springer
Background Neuroblastoma (NB) is a heterogeneous embryonal malignancy and the
deadliest tumor of infancy. It is a complex disease that can result in diverse clinical …

Schwann cell‐derived exosomes promote lung cancer progression via miRNA‐21‐5p

Y Zhou, Y Zhang, J Xu, Y Wang, Y Yang, W Wang… - Glia, 2024 - Wiley Online Library
Schwann cells (SCs), the primary glial cells of the peripheral nervous system, which have
been identified in many solid tumors, play an important role in cancer development and …

[HTML][HTML] Regulation of carcinogenesis by sensory neurons and neuromediators

N Erin, GV Shurin, JH Baraldi, MR Shurin - Cancers, 2022 - mdpi.com
Simple Summary Sensory nerve fibers extensively innervate the entire body. They are the
first to sense danger signals, including the ones coming from newly formed cancer cells …

[HTML][HTML] Development and in vitro differentiation of Schwann cells

SJ Hörner, N Couturier, DC Gueiber, M Hafner… - Cells, 2022 - mdpi.com
Schwann cells are glial cells of the peripheral nervous system. They exist in several
subtypes and perform a variety of functions in nerves. Their derivation and culture in vitro are …