In a European BIOMED-2 collaborative study, multiplex PCR assays have successfully been
developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) …

B cell chronic lymphocytic leukemia (B-CLL) is an accumulative disease of slowly
proliferating CD5+ B lymphocytes that develops in the aging population. Whereas some …

To better understand the stage (s) of differentiation reached by B-type chronic lymphocytic
leukemia (B-CLL) cells and to gain insight into the potential role of antigenic stimulation in …

We quantify the VDJ recombination and somatic hypermutation processes in human B cells
using probabilistic inference methods on high-throughput DNA sequence repertoires of …

To understand better how selection processes balance the benefits of Ig repertoire diversity
with the risks of autoreactivity and nonfunctionality of highly variable IgH CDR3s, we …

Two neutralizing human mAbs, 2F5 and 4E10, that react with the HIV-1 envelope gp41
membrane proximal region are also polyspecific autoantibodies that bind to anionic …

Over the past twenty years diverse groups in Northeast Asia, Western Europe, and North
America have competed to map, sequence, and characterize the immunoglobulin loci of …

The human fetus and neonate are unduly susceptible to infection with a number of bacterial,
fungal, protozoal, and viral agents, many of which are not pathogenic in older children and …

Develo** B cells must pass a series of checkpoints that are regulated by membrane-
bound Igμ through the Igα-Igβ signal transducers. To determine how Igμ expression affects B …

Antibody variable regions are composed of a heavy and a light chain, and in humans, there
are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing …