In the drug discovery setting, undesirable ADMET properties of a pharmacophore with good
predictive power obtained after a tedious drug discovery and development process may …

Antibiotic resistance continues to be a most serious threat to public health. This situation
demands that the scientific community increase their efforts for the discovery of alternative …

Prostate cancer (PC) is the second most common tumor in males worldwide. The lack of
effective medication and the development of multidrug resistance towards current …

Colorectal cancer (CRC) is the most frequent form of gastrointestinal cancer and one of the
major causes of human mortality worldwide. Many of the current CRC therapies have …

Insecticide resistance jeopardizes the prevention of infectious diseases such as malaria and
dengue fever by vector control of disease-transmitting mosquitoes. Effective new insecticidal …

Abstract Series of 7‐(Trifluoromethyl) substituted indolizine 4a‐g was synthesized using the
one‐pot method. Spectroscopic techniques such as IR, 1H‐NMR, 13C‐NMR, and HRMS …

The cyclooxygenase-2 (COX-2) enzyme is an important target for drug discovery and
development of novel anti-inflammatory agents. Selective COX-2 inhibitors have the …

The ongoing study reports the synthesis, spectroscopic analyses and larvicidal efficacy of
novel series of quinazolinone derivatives and related compounds. The structures of the …

Abstract Interaction of 2-furylvinyl-and 2-thienylvinyl-2, 3-dihydroquinazolin-4 (1H)-ones with
maleic anhydride gives isoindolo [2, 1-a] quinazoline-11 (13)-carboxylic acids via the …

A series of 2, 3-dihydroquinazolin-4 (1 H)-one derivatives (3a–3m) was screened for in vitro
whole-cell antitubercular activity against the tubercular strain H37Rv and multidrug-resistant …