Engineered in vitro disease models
The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …
human disease or to develop new and improved therapies or diagnostics. Although great …
Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility
G Fiorentino, D Cimadomo, F Innocenti… - Human …, 2023 - academic.oup.com
BACKGROUND Folliculogenesis occurs in the highly dynamic environment of the ovary.
Follicle cyclic recruitment, neo-angiogenesis, spatial displacement, follicle atresia and …
Follicle cyclic recruitment, neo-angiogenesis, spatial displacement, follicle atresia and …
A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice
Emerging additive manufacturing techniques enable investigation of the effects of pore
geometry on cell behavior and function. Here, we 3D print microporous hydrogel scaffolds to …
geometry on cell behavior and function. Here, we 3D print microporous hydrogel scaffolds to …
Bioengineering trends in female reproduction: a systematic review
BACKGROUND To provide the optimal milieu for implantation and fetal development, the
female reproductive system must orchestrate uterine dynamics with the appropriate …
female reproductive system must orchestrate uterine dynamics with the appropriate …
Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices
Fibrosis is a hallmark of aging tissues which often leads to altered architecture and function.
The ovary is the first organ to show overt signs of aging, including increased fibrosis in the …
The ovary is the first organ to show overt signs of aging, including increased fibrosis in the …
Initiation of puberty in mice following decellularized ovary transplant
Clinical interventions to preserve fertility and restore hormone levels in female patients with
therapy-induced ovarian failure are insufficient, particularly for pediatric cancer patients …
therapy-induced ovarian failure are insufficient, particularly for pediatric cancer patients …
Three-dimensional bioprinting of artificial ovaries by an extrusion-based method using gelatin-methacryloyl bioink
T Wu, YY Gao, J Su, XN Tang, Q Chen, LW Ma… - …, 2022 - Taylor & Francis
Purpose The aim of this study was to design and fabricate a three-dimensional (3D) printed
artificial ovary. Methods We first compared the printability of gelatin-methacryloyl (GelMA) …
artificial ovary. Methods We first compared the printability of gelatin-methacryloyl (GelMA) …
Vitamin C in stem cell biology: impact on extracellular matrix homeostasis and epigenetics
Transcription factors and signaling molecules are well‐known regulators of stem cell identity
and behavior; however, increasing evidence indicates that environmental cues contribute to …
and behavior; however, increasing evidence indicates that environmental cues contribute to …
Ameliorating effects of natural antioxidant compounds on female infertility: a review
JK Bhardwaj, H Panchal, P Saraf - Reproductive sciences, 2021 - Springer
The prevalence of female infertility cases has been increasing at a frightening rate, affecting
approximately 48 million women across the world. However, oxidative stress has been …
approximately 48 million women across the world. However, oxidative stress has been …
Follicle development as an orchestrated signaling network in a 3D organoid
The ovarian follicle is the structural and functional unit of the ovary, composed of the female
gamete (the oocyte) and supportive somatic cells. Follicles are not only the source of a …
gamete (the oocyte) and supportive somatic cells. Follicles are not only the source of a …