Hydrocephalus is the most common neurosurgical disorder worldwide and is characterized
by enlargement of the cerebrospinal fluid (CSF)-filled brain ventricles resulting from failed …

Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …

When challenged by hypertonicity, dehydrated cells must recover their volume to survive.
This process requires the phosphorylation-dependent regulation of SLC12 cation chloride …

Dietary potassium deficiency, common in modern diets, raises blood pressure and
enhances salt sensitivity. Potassium homeostasis requires a molecular switch in the distal …

Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

The WNK-SPAK/OSR1 kinase complex is composed of the kinases WNK (with no lysine)
and SPAK (SPS1-related proline/alanine-rich kinase) or the SPAK homolog OSR1 (oxidative …

Dietary potassium deficiency activates thiazide-sensitive sodium chloride cotransport along
the distal nephron. This may explain, in part, the hypertension and cardiovascular mortality …

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets
(the SPAK/OSR1 kinases and the cation-Cl− cotransporters [CCCs]), comprise a signaling …

The discovery of four genes responsible for pseudohypoaldosteronism type II, or familial
hyperkalemic hypertension, which features arterial hypertension with hyperkalemia and …