Genomic and phenotypic heterogeneity in prostate cancer

MC Haffner, W Zwart, MP Roudier, LD True… - Nature Reviews …, 2021 - nature.com
From a clinical, morphological and molecular perspective, prostate cancer is a
heterogeneous disease. Primary prostate cancers are often multifocal, having …

Recent advances in development of dendritic polymer‐based nanomedicines for cancer diagnosis

H Li, J Sun, H Zhu, H Wu, H Zhang… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Dendritic polymers have highly branched three‐dimensional architectures, the fourth type
apart from linear, cross‐linked, and branched one. They possess not only a large number of …

Artificial intelligence in medical imaging: switching from radiographic pathological data to clinically meaningful endpoints

O Oren, BJ Gersh, DL Bhatt - The Lancet Digital Health, 2020 - thelancet.com
Artificial intelligence (AI) is a disruptive technology that involves the use of computerised
algorithms to dissect complicated data. Among the most promising clinical applications of AI …

Serum PSA-based early detection of prostate cancer in Europe and globally: past, present and future

H Van Poppel, T Albreht, P Basu, R Hogenhout… - Nature Reviews …, 2022 - nature.com
In the pre-PSA-detection era, a large proportion of men were diagnosed with metastatic
prostate cancer and died of the disease; after the introduction of the serum PSA test …

A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging

H Lu, A Chen, X Zhang, Z Wei, R Cao, Y Zhu… - Nature …, 2022 - nature.com
Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health
conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent …

Artificial intelligence in oncology: current capabilities, future opportunities, and ethical considerations

JT Shreve, SA Khanani, TC Haddad - American Society of Clinical …, 2022 - ascopubs.org
The promise of highly personalized oncology care using artificial intelligence (AI)
technologies has been forecasted since the emergence of the field. Cumulative advances …

Positive predictive value of prostate imaging reporting and data system version 2 for the detection of clinically significant prostate cancer: a systematic review and meta …

E Mazzone, A Stabile, F Pellegrino, G Basile… - European urology …, 2021 - Elsevier
Context The variability of the positive predictive value (PPV) represents a significant factor
affecting the diagnostic performance of multiparametric magnetic resonance imaging …

Considering the role of radical prostatectomy in 21st century prostate cancer care

AJ Costello - Nature Reviews Urology, 2020 - nature.com
The practice of radical prostatectomy for treating prostate cancer has evolved remarkably
since its general introduction around 1900. Initially described using a perineal approach, the …

Interactive explainable deep learning model informs prostate cancer diagnosis at MRI

CA Hamm, GL Baumgärtner, F Biessmann, NL Beetz… - Radiology, 2023 - pubs.rsna.org
Background Clinically significant prostate cancer (PCa) diagnosis at MRI requires accurate
and efficient radiologic interpretation. Although artificial intelligence may assist in this task …

Combined diffusion‐relaxometry microstructure imaging: Current status and future prospects

PJ Slator, M Palombo, KL Miller… - Magnetic resonance …, 2021 - Wiley Online Library
Microstructure imaging seeks to noninvasively measure and map microscopic tissue
features by pairing mathematical modeling with tailored MRI protocols. This article reviews …