In response to improper kinetochore-microtubule attachments in mitosis, the spindle
assembly checkpoint (SAC) assembles the mitotic checkpoint complex (MCC) to inhibit the …

The spindle assembly checkpoint (SAC) is a cellular surveillance mechanism that functions
to ensure accurate chromosome segregation during mitosis. Macromolecular complexes …

Mitotic checkpoints orchestrate cell division through intricate molecular networks that ensure
genomic stability. While experimental research has uncovered key aspects of checkpoint …

During mitosis, unattached kinetochores in a dividing cell signal to the spindle assembly
checkpoint (SAC) to delay anaphase onset and prevent chromosome missegregation. 1, 2 …

During mitosis, unattached kinetochores trigger the spindle assembly checkpoint by
promoting assembly of the mitotic checkpoint complex, a heterotetramer comprising Mad2 …

Background The establishment of kinetochore–microtubule attachment is essential for error‐
free chromosome alignment and segregation during cell division. Defects in chromosome …

We previously identified a cell cycle-dependent periodic subcellular distribution of cancer
metastasis-associated antigen 1 (MTA1) and unraveled a novel role of MTA1 in inhibiting …

Ovarian cancer develops insidiously and is frequently diagnosed at advanced stages.
Screening for ovarian cancer is an effective strategy for reducing mortality. This study aimed …

The spindle assembly checkpoint (SAC) makes mitotic exit contingent on completion of
sister chromatid biorientation, but how this coordination is achieved in practice remains …