Small molecules in the treatment of COVID-19
S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19
ABSTRACT Introduction: The current SARS-CoV-2 pandemic urgently demands for both
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
Targeting the RdRp of emerging RNA viruses: the structure-based drug design challenge
The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral
replication process, catalyzing the viral RNA synthesis using a metal ion-dependent …
replication process, catalyzing the viral RNA synthesis using a metal ion-dependent …
Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic
As of today, there is no antiviral for the treatment of the SARS-CoV-2 infection, and the
development of a vaccine might take several months or even years. The structural …
development of a vaccine might take several months or even years. The structural …
Repurposing drugs for the management of COVID-19
J Cusinato, Y Cau, AM Calvani… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 represents
a serious health issue worldwide, with more than 61 million cases and more than 1.4 million …
a serious health issue worldwide, with more than 61 million cases and more than 1.4 million …
[HTML][HTML] Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity
Background and Aims Oxidative stress plays a key role in the development of metabolic
complications associated with obesity, including insulin resistance and the most common …
complications associated with obesity, including insulin resistance and the most common …
Therapeutics for flaviviral infections
AM Bifani, KWK Chan, D Borrenberghs, MJA Tan… - Antiviral Research, 2023 - Elsevier
Flaviviruses are vector-borne pathogens capable of causing devastating human diseases.
The re-emergence of Zika in 2016 notoriously led to a widescale epidemic in the Americas …
The re-emergence of Zika in 2016 notoriously led to a widescale epidemic in the Americas …
[HTML][HTML] Efficacy and safety of sofosbuvir/ledipasvir in treatment of patients with COVID-19; A randomized clinical trial
Background: There is no study regarding the use of SOF/LDP in treatment of COVID-19.
Objectives: In this study, the efficacy and safety of SOF/LDP were assessed in treatment of …
Objectives: In this study, the efficacy and safety of SOF/LDP were assessed in treatment of …
Drug repurposing strategies and key challenges for COVID-19 management
COVID-19 is a clinical outcome of viral infection emerged due to strain of beta coronavirus
which attacks the type-2 pneumocytes in alveoli via angiotensin-converting enzyme 2 …
which attacks the type-2 pneumocytes in alveoli via angiotensin-converting enzyme 2 …
Pathogenicity and virulence of West Nile virus revisited eight decades after its first isolation
JC Saiz, MA Martín-Acebes, AB Blázquez… - Virulence, 2021 - Taylor & Francis
West Nile virus (WNV) is a flavivirus which transmission cycle is maintained between
mosquitoes and birds, although it occasionally causes sporadic outbreaks in horses and …
mosquitoes and birds, although it occasionally causes sporadic outbreaks in horses and …