Understanding inbreeding depression, purging, and genetic rescue

PW Hedrick, A Garcia-Dorado - Trends in ecology & evolution, 2016 - cell.com
Inbreeding depression, the reduction of fitness caused by inbreeding, is a nearly universal
phenomenon that depends on past mutation, selection, and genetic drift. Recent estimates …

Challenges in analysis and interpretation of microsatellite data for population genetic studies

AI Putman, I Carbone - Ecology and evolution, 2014 - Wiley Online Library
Advancing technologies have facilitated the ever‐widening application of genetic markers
such as microsatellites into new systems and research questions in biology. In light of the …

[BOOK][B] Molecular ecology

JR Freeland - 2020 - books.google.com
A fully updated guide to the increasingly prevalent use of molecular data in ecological
studies Molecular ecology is concerned with how molecular biology and population genetics …

Genetics and the conservation of natural populations: allozymes to genomes

FW Allendorf - 2017 - Wiley Online Library
I consider how the study of genetic variation has influenced efforts to conserve natural
populations over the last 50 years. Studies with allozymes in the 1970s provided the first …

Genomics advances the study of inbreeding depression in the wild

M Kardos, HR Taylor, H Ellegren… - Evolutionary …, 2016 - Wiley Online Library
Inbreeding depression (reduced fitness of individuals with related parents) has long been a
major focus of ecology, evolution, and conservation biology. Despite decades of research …

Measuring individual inbreeding in the age of genomics: marker-based measures are better than pedigrees

M Kardos, G Luikart, FW Allendorf - Heredity, 2015 - nature.com
Inbreeding (mating between relatives) can dramatically reduce the fitness of offspring by
causing parts of the genome to be identical by descent. Thus, measuring individual …

Genomic consequences of intensive inbreeding in an isolated wolf population

M Kardos, M Åkesson, T Fountain, Ø Flagstad… - Nature ecology & …, 2018 - nature.com
Inbreeding (mating between relatives) is a major concern for conservation as it decreases
individual fitness and can increase the risk of population extinction. We used whole-genome …

inbreedR: an R package for the analysis of inbreeding based on genetic markers

MA Stoffel, M Esser, M Kardos… - Methods in Ecology …, 2016 - Wiley Online Library
Heterozygosity–fitness correlations (HFCs) have been widely used to explore the impact of
inbreeding on individual fitness. Initially, most studies used small panels of microsatellites …

High-throughput sequencing reveals inbreeding depression in a natural population

JI Hoffman, F Simpson, P David… - Proceedings of the …, 2014 - National Acad Sciences
Proxy measures of genome-wide heterozygosity based on approximately 10 microsatellites
have been used to uncover heterozygosity fitness correlations (HFCs) for a wealth of …

Genetic diversity in fishes is influenced by habitat type and life‐history variation

AS Martinez, JR Willoughby… - Ecology and …, 2018 - Wiley Online Library
Populations of fishes are increasingly threatened by over‐exploitation, pollution, habitat
destruction, and climate change. In order to better understand the factors that can explain …