CD4+ T cells are effector T cells (Teffs) produced by the differentiation of initial T cells in
peripheral lymphoid tissue after being attacked by antigens, and have an indispensable role …

The tumor suppressor p53 plays various functional roles in the cell by regulating multiple
regulatory signals that ensure adequate temporal and spatial responses to cellular stress …

Dengue virus and other flaviviruses such as the yellow fever, West Nile, and Japanese
encephalitis viruses are emerging vector‐borne human pathogens that affect annually more …

Sumoylation is a transient, reversible dynamic posttranslational modification that regulates
diverse cellular processes including plant-pathogen interactions. Sumoylation of NPR1, a …

UBC9, the sole E2-conjugating enzyme required for SUMOylation, is a key regulator of
essential cellular functions and, as such, is frequently altered in cancers. Along these lines …

Ubiquitin-conjugating enzymes (E2s) are one of the three enzymes required by the ubiquitin-
proteasome pathway to connect activated ubiquitin to target proteins via ubiquitin ligases …

Short linear motifs (SLiM) are short peptides that facilitate protein function and protein-
protein interactions. Viruses utilize these motifs to enter into the host, interact with cellular …

Many cellular processes pertinent for viral infection are regulated by the addition of small
ubiquitin-like modifiers (SUMO) to key regulatory proteins, making SUMOylation an …

SUMOylation has emerged as an important post-translational modification that involves the
covalent attachment of the Small Ubiquitin-like Modifier (SUMO) polypeptide to a lysine …

The human adenovirus species C type 5 (HAdV-C5) early region 1B 55 kDa (E1B-55K)
protein is a multifunctional protein that promotes viral replication and adenovirus-mediated …