Background Septic shock is the most severe form of sepsis, in which profound underlying
abnormalities in circulatory and cellular/metabolic parameters lead to substantially …

Management bundles that define items or procedures strongly recommended in clinical
practice have been used in many guidelines in recent years. Application of these bundles …

The “sepsis bundle” has been central to the implementation of the Surviving Sepsis
Campaign (SSC) from the first publication of its evidence-based guidelines in 2004 through …

Background There is a need to better define the epidemiology of sepsis in intensive care
units (ICUs) around the globe. Methods The Intensive Care over Nations (ICON) audit …

Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of
sepsis and propose the evolution of a new phenotype of critically ill patients, its potential …

Background: Sepsis is a global healthcare issue and continues to be the leading cause of
death from infection. Early recognition and diagnosis of sepsis is required to prevent the …

Purpose We assessed the effects of a protocol restricting resuscitation fluid vs. a standard
care protocol after initial resuscitation in intensive care unit (ICU) patients with septic shock …

Abstract Changes in position is one of the nursing interventions in the management of
patients with mechanical ventilation. Several studies found contradictory effects in different …