The directed aldol reaction allows the construction of new carbon–carbon bonds in a regio‐,
diastereo‐, and enantioselective manner. The kinetically controlled, boron‐mediated aldol …

Four decades since Mukaiyama's first reports on the successful application of silicon and
boron enolates in directed aldol reactions, the ability of this highly controlled carbon–carbon …

Natural products of propionate origin such as macrolide antibiotics often contain both anti-
and syn-3-hydroxy-2-methylcarbonyl units (1 and 2) in their structural framework. While the …

A practical stereocontrolled synthesis of (+)-discodermolide (1) has been completed in
10.3% overall yield (23 steps longest linear sequence). The absolute stereochemistry of the …

Stille reaction is one of the most common, efficient and selective Pd-catalyzed cross-
coupling reactions for the construction of CC bonds in the art of organic synthesis. It was …

Nature employs dihydroxyacetone phosphate (DHAP) as the donor component in various
enzyme‐catalyzed aldol reactions. Probably the most significant example in this regard is …

The diverse and complex structures of polyketide natural products have stimulated the
imagination of synthetic chemists for decades. Captivated by their often impressive …

Covering: 1993 to 2007 Initially isolated in trace quantities from deep-sea sponges, the
structurally related polyketides discodermolide and dictyostatin share the same microtubule …

The convergent, highly enantioselective synthesis of rhizoxin D, a natural product
possessing potent antitumor and antifungal bioactivity, is described. The C (1)− C (9) …

The boron-mediated, anti-selective, aldol reactions of ketone 2 (and related derivatives)
proceed with high levels of asymmetric induction, diastereoselectivities of up to 200: 1 in …