Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the expansion
of immature myeloid cells in the bone marrow (BM) and peripheral blood (PB) resulting in …

Abstract Background and Purpose Currently there are no widely accepted guidelines for
chimerism analysis testing in hematopoietic cell transplantation (HCT) patients. The …

This review highlights literature pertinent to chimerism analysis in the context of
hematopoietic cell transplantation (HCT). We also conducted a survey of testing practices of …

Lack of HLA-matched related/unrelated donor remains a barrier to allogeneic hematopoietic
cell transplantation (HCT) for adult acute myeloid leukemia (AML), with ongoing uncertainty …

Over the last decades, significant improvements in reducing the toxicities of allogeneic
hematopoietic cell transplantation (allo-HCT) have widened its use as consolidation or …

Importance Patient-specific human leukocyte antigen (HLA) genomic loss (HLA loss) is one
of the reputed mechanisms of leukemia immune escape and relapse after haploidentical …

Disease relapse represents by far the most frequent cause of hematopoietic cell
transplantation (HCT) failure. Patients with acute leukemia suffering relapse after HCT have …

Genomic loss of mismatched human leukocyte antigen (HLA loss) is one of the most vital
immune escape mechanisms of leukemic cells after allogeneic hematopoietic stem cell …

HLA loss in hematologic malignancies is rare at diagnosis but may occur in leukemic cells at
disease relapse. Although HLA mismatched hematopoietic cell transplant (HCT) is useful in …

Despite the considerable improvements witnessed over the last few decades in the
feasibility and safety of allogeneic hematopoietic cell transplantation (allo-HCT) for …