Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and
clinical studies but may be difficult to sustain. As an alternative to CR, there has been …

The vulnerability of cancer cells to nutrient deprivation and their dependency on specific
metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) …

Tumours depend on nutrients supplied by the host for their growth and survival.
Modifications to the host's diet can change nutrient availability in the tumour …

Humans in modern societies typically consume food at least three times daily, while
laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns …

Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …

Fasting has been practiced for millennia, but, only recently, studies have shed light on its
role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize …

Background: The problems of adherence to energy restriction in humans are well known.
Objective: To compare the feasibility and effectiveness of intermittent continuous energy …

Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …

Calorie restriction (CR) is the only experimental manipulation that is known to extend the
lifespan of a number of organisms including yeast, worms, flies, rodents and perhaps non …

Human aging is currently defined as a physiological decline of biological functions in the
body with a continual adaptation to internal and external damaging. The endocrine system …