Chinese hamster ovary (CHO) cells represent the most frequently applied host cell system
for industrial manufacturing of recombinant protein therapeutics. CHO cells are capable of …

Mammalian cell expression has become the dominant recombinant protein production
system for clinical applications because of its capacity for post-translational modification and …

In the biopharmaceutical industry, mammalian cell culture systems, especially Chinese
hamster ovary (CHO) cells, are predominantly used for the production of therapeutic …

There has been a rapid increase in the number and demand for approved
biopharmaceuticals produced from animal cell culture processes over the last few years. In …

Almost all of the 200 or so approved biopharmaceuticals have been produced in one of
three host systems: the bacterium Escherichia coli, yeasts (Saccharomyces cerevisiae …

Fed‐batch Chinese hamster ovary (CHO) cell culture is the most commonly used process for
IgG production in the biopharmaceutical industry. Amino acid and glucose consumption, cell …

The glycoprotein hormone erythropoietin (EPO) is an essential viability and growth factor for
the erythrocytic progenitors. EPO is mainly produced in the kidneys. EPO gene expression is …

In recent years, the number of recombinant proteins used for therapeutic applications has
increased dramatically. Many of these applications involve complex glycoproteins and …

In the light of the enthusiasm regarding the use of recombinant human erythropoietin (Epo)
and its analogues for treatment of the anaemias of chronic renal failure and malignancies it …

Proteins started being used as pharmaceuticals in the 1920s with insulin extracted from pig
pancreas. In the early 1980s, human insulin was prepared in recombinant bacteria and it is …