In the past decade, extracellular vesicles (EVs) have emerged as key regulators of bone
development, homeostasis and repair. EV-based therapies have the potential to …

Recent studies have revealed the vital role of MSCs in bone regeneration. In both self-
healing bone regeneration processes and biomaterial-induced healing of bone defects …

Extracellular vesicles (EVs) have garnered growing attention as promising acellular tools for
bone repair. Although EVs' potential for bone regeneration has been shown, issues …

Age-associated bone diseases such as osteoporosis (OP) are common in the elderly due to
skeletal ageing. The process of skeletal ageing can be accelerated by reduced proliferation …

Mesenchymal stem cells (MSCs) are a promising cell population for regenerative medicine
applications, where paracrine signalling through the extracellular vesicles (EVs) regulates …

Extracellular Vesicles (EVs) are considered promising nanoscale therapeutics for bone
regeneration. To date, EVs are typically procured from cells on 2D tissue culture plastic, an …

Epigenetics plays a critical role in regulating mesenchymal stem cells'(MSCs) fate for tissue
repair and regeneration. There is increasing evidence that the inhibition of histone …

Alterations to the human organism that are brought about by aging are comprehensive and
detrimental. Of these, an imbalance in bone homeostasis is a major outward manifestation of …

Epigenetic approaches using the histone deacetylase 2 and 3 inhibitor-MI192 have been
reported to accelerate stem cells to form mineralised tissues. Gelatine methacryloyl (GelMA) …

Background A variety of proteins including epigenetic factors are involved in the
differentiation of human bone marrow mesenchymal stem cells. These cells also exhibited …