Initiation of mRNA translation is a major checkpoint for regulating level and fidelity of protein
synthesis. Being rate limiting in protein synthesis, translation initiation also represents the …

Other than the start codon, the Shine-Dalgamo region is the only primary sequence element
that has been unequivocally demonstrated to be directly involved in translational initiation …

We have quantitatively analyzed the relationship between translational efficiency and the
mRNA secondary structure in the initiation region. The stability of a defined hairpin structure …

Escherichia coli (E. coli) mazEF is a stress-induced toxin-antitoxin (TA) module. The toxin
MazF is an endoribonuclease that cleaves single-stranded mRNAs at ACA sequences …

The translational roles of the Shine‐Dalgarno sequence, the initiation codon, the space
between them, and the second codon have been studied. The Shine Dalgarno sequence …

The ribosome selects aminoacyl-tRNA (aa-tRNA) matching to the mRNA codon from the
bulk of nonmatching aa-tRNAs in two consecutive selection steps, initial selection and …

Small noncoding RNAs (sRNAs) have predominantly been shown to repress bacterial
mRNAs by masking the Shine-Dalgarno (SD) or AUG start codon sequence, thereby …

Ribosomes complexed with synthetic mRNA and peptidyl‐tRNA, ready for peptide release,
were purified by gel filtration and used to study the function of release factor RF3 and …

The modest correlation between mRNA expression and protein abundance in large-scale
data sets is explained in part by experimental challenges, such as technological limitations …

Binding of aminoglycoside antibiotics to 16S ribosomal RNA induces a particular structure of
the decoding center and increases the misincorporation of near-cognate amino acids. By …