Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate
energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid …

The brain plays a key role in the controls of energy intake and expenditure, and many genes
associated with obesity are expressed in the central nervous system. Technological and …

Positron emission tomography (PET) imaging is based on detecting two time-coincident high-
energy photons from the emission of a positron-emitting radioisotope. The physics of the …

Background Obesity results from an imbalance between energy intake and expenditure. In
rodents and newborn humans, brown adipose tissue helps regulate energy expenditure by …

Background Studies in animals indicate that brown adipose tissue is important in the
regulation of body weight, and it is possible that individual variation in adaptive …

Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are
typically measured by imaging [18F] fluorodeoxyglucose (FDG) uptake in response to cold …

OBJECTIVE The significant roles of brown adipose tissue (BAT) in the regulation of energy
expenditure and adiposity are established in small rodents but have been controversial in …

Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat
as a defense against cold and excessive feeding. Interest in the field of BAT biology has …