Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: the role of the complement and innate immune system

JJ Provencio, S Inkelas, MDI Vergouwen - Translational Stroke Research, 2024 - Springer
Specific inflammatory pathways are important in the development of delayed cerebral
ischemia after aneurysmal subarachnoid hemorrhage. Understanding the specific pathways …

[HTML][HTML] Inflammatory pathogenesis of post-stroke depression

X Feng, X Ma, J Li, Q Zhou, Y Liu, J Song… - Aging and …, 2024 - pmc.ncbi.nlm.nih.gov
Post-stroke depression (PSD) is a complex mood disorder that emerges in individuals
following a stroke, characterized by the development of depressive symptoms. The …

[HTML][HTML] Nrf2 activation by neferine mitigates microglial neuroinflammation after subarachnoid hemorrhage through inhibiting TAK1-NF-κB signaling

X Zhang, J Li, C Cao, Z Liu, Q Chen, Z Gu… - International …, 2024 - Elsevier
Oxidative stress and neuroinflammation are two major causes leading to early brain injury
after subarachnoid hemorrhage (SAH). Nuclear factor E2-related factor 2 (Nrf2) is a critical …

The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial

G Tan, AL Huguenard, KM Donovan, P Demarest, X Liu… - Elife, 2025 - elifesciences.org
Background: Subarachnoid hemorrhage (SAH) is characterized by intense central
inflammation, leading to substantial post-hemorrhagic complications such as vasospasm …

Transcriptomics and metabolomics reveal hypothalamic metabolic characteristics and key genes after subarachnoid hemorrhage in rats

Z Liu, Z Chai, F Wu, L Zhang, X Wang, Z Xu… - Metabolic Brain …, 2024 - Springer
Subarachnoid hemorrhage (SAH) is a serious hemorrhagic event with high mortality and
morbidity. Multiple injurious events produced by SAH can lead to a series of …

Role of neutrophils as therapeutic targets in intracerebral hemorrhage

AF Ardic, N Ardic - Therapeutic Innovation & Regulatory Science, 2024 - Springer
Intracerebral hemorrhage (ICH) is a major health problem. It is one of the most common
types of stroke and results in mortality in approximately half of patients. More than half of the …

Trajectory clustering of immune cells and its association with clinical outcomes after aneurysmal subarachnoid hemorrhage

SY Won, M Kim, HG Jeong, BSK Yang, HA Choi… - Frontiers in …, 2024 - frontiersin.org
Background and purpose The immune response following aneurysmal subarachnoid
hemorrhage (aSAH) can exacerbate secondary brain injury and impact clinical outcomes …

Identification of key genes and immune infiltration in peripheral blood biomarker analysis of delayed cerebral ischemia: Valproic acid as a potential therapeutic drug

Z Wu, Z Zhao, Y Li, C Wang, C Cheng, H Li… - International …, 2024 - Elsevier
Background Delayed cerebral ischemia (DCI) is a common and serious complication of
subarachnoid hemorrhage (SAH). Its pathogenesis is not fully understood. Here, we …

[HTML][HTML] Therapeutic Role of Microglia/Macrophage Polarization in Intracerebral Hemorrhage

R Dinc, N Ardic - Clinical and Translational Neuroscience, 2025 - mdpi.com
Intracerebral hemorrhage (ICH) is a significant health problem with high mortality and
morbidity rates, partly due to limited treatment options. Hematoma after ICH causes …

immunologic implications for stroke recovery: unveiling the role of the immune system in pathogenesis, neurorepair, and rehabilitation

G Hey, S Bhutani, MG Woolridge… - Journal of cellular …, 2023 - scientificarchives.com
Stroke is a debilitating neurologic condition characterized by an interruption or complete
blockage of blood flow to certain areas of the brain. While the primary injury occurs at the …