Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …

The immunosuppressive action of the calcineurin inhibitor cyclosporine A (CsA) stems from
the inhibition of nuclear factor of activated T cells (NFAT) signaling in T cells. CsA is also …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

Podocytes of the renal glomerulus are unique cells with a complex cellular organization
consisting of a cell body, major processes and foot processes. Podocyte foot processes form …

An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

The transient receptor potential (TRP) superfamily of channels comprises a diverse group of
cation channels. Four TRP channel subunits coassemble to form functional homo-or …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2
diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease …

Human genetic and in vivo studies have helped to define the critical importance of
podocytes for kidney function in health and disease. However, as in any other research …