T cells of the γδ lineage are unconventional T cells with functions not restricted to MHC-
mediated antigen presentation. Because of their broad antigen specificity and NK-like …

Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …

Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive
immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying …

The microbiome plays a fundamental role in how the immune system develops and how
inflammatory responses are shaped and regulated. The “gut-lung axis” is a relatively new …

Studies of human lung development have focused on epithelial and mesenchymal cell types
and function, but much less is known about the develo** lung immune cells, even though …

Clonal expansion of antigen‐specific lymphocytes is the fundamental mechanism enabling
potent adaptive immune responses and the generation of immune memory. Accompanied …

While γδ T cells are present virtually in all vertebrates, there is a remarkable lack of
conservation of the TRG and TRD loci underlying the generation of the γδ T cell receptor …

Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and regulate tissue
homeostasis and immunity. ILCs are divided into 3 groups, group 1 ILCs, group 2 ILCs, and …

The discovery of innate lymphoid cells (ILCs) has revolutionized our understanding of innate
immunity and immune cell interactions at epithelial barrier sites. Their presence and …

Increased production of Prostaglandin D2 (PGD2) is linked to development and progression
of asthma and allergy. PGD2 is rapidly degraded to its metabolites, which initiate type 2 …