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From digital control to digital twins in medicine: A brief review and future perspectives
R Eftimie, A Mavrodin, SPA Bordas - Advances in Applied Mechanics, 2023 - Elsevier
The last few decades have been dominated by the need for digital control of various
processes in biology and medicine. Advances in artificial intelligence (AI) over the last few …
processes in biology and medicine. Advances in artificial intelligence (AI) over the last few …
Sobol sensitivity analysis: a tool to guide the development and evaluation of systems pharmacology models
A systems pharmacology model typically integrates pharmacokinetic, biochemical network,
and systems biology concepts into a unifying approach. It typically consists of a large …
and systems biology concepts into a unifying approach. It typically consists of a large …
Global sensitivity analysis of biological multiscale models
M Renardy, C Hult, S Evans, JJ Linderman… - Current opinion in …, 2019 - Elsevier
Mathematical models of biological systems need to both reflect and manage the inherent
complexities of biological phenomena. Through their versatility and ability to capture …
complexities of biological phenomena. Through their versatility and ability to capture …
Virtual populations for quantitative systems pharmacology models
Quantitative systems pharmacology (QSP) places an emphasis on dynamic systems
modeling, incorporating considerations from systems biology modeling and …
modeling, incorporating considerations from systems biology modeling and …
Quantification of pathway cross-talk reveals novel synergistic drug combinations for breast cancer
S Jaeger, A Igea, R Arroyo, V Alcalde, B Canovas… - Cancer …, 2017 - aacrjournals.org
Combinatorial therapeutic approaches are an imperative to improve cancer treatment,
because it is critical to impede compensatory signaling mechanisms that can engender drug …
because it is critical to impede compensatory signaling mechanisms that can engender drug …
Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways
J Tang, L Karhinen, T Xu, A Szwajda… - PLoS computational …, 2013 - journals.plos.org
A recent trend in drug development is to identify drug combinations or multi-target agents
that effectively modify multiple nodes of disease-associated networks. Such …
that effectively modify multiple nodes of disease-associated networks. Such …
[HTML][HTML] Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance
HS Khalil, V Mitev, T Vlaykova, L Cavicchi… - Journal of …, 2015 - Elsevier
Seliciclib (R-Roscovitine) was identified as an inhibitor of CDKs and has undergone drug
development and clinical testing as an anticancer agent. In this review, the authors describe …
development and clinical testing as an anticancer agent. In this review, the authors describe …
The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes
How cell fate (survival or death) is determined and whether such determination depends on
the strength of stimulation has remained unclear. In this study, we discover that the cell fate …
the strength of stimulation has remained unclear. In this study, we discover that the cell fate …
From cold to hot: changing perceptions and future opportunities for quantitative systems pharmacology modeling in cancer immunotherapy
V Lemaire, D Bassen, M Reed, R Song… - Clinical …, 2023 - Wiley Online Library
Immuno‐oncology (IO) is a fast‐expanding field due to recent success using IO therapies in
treating cancer. As IO therapies do not directly kill tumor cells but rather act upon the …
treating cancer. As IO therapies do not directly kill tumor cells but rather act upon the …
Assessing convergence in global sensitivity analysis: a review of methods for assessing and monitoring convergence
X Sun, AJ Jakeman, BFW Croke, SG Roberts… - Socio-Environmental …, 2024 - sesmo.org
In global sensitivity analysis (GSA) of a model, a proper convergence analysis of metrics is
essential for ensuring a level of confidence or trustworthiness in sensitivity results obtained …
essential for ensuring a level of confidence or trustworthiness in sensitivity results obtained …