Both aging and cancer are characterized by a series of partially overlap**" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Mutations in the TP53 tumour suppressor gene are very frequent in cancer, and attempts to
restore the functionality of p53 in tumours as a therapeutic strategy began decades ago …

Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology …

Although p53 inactivation promotes genomic instability and presents a route to malignancy
for more than half of all human cancers,, the patterns through which heterogenous TP53 …

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation
in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs …

INTRODUCTION The microbiota promotes the maturation and homeostasis of the immune
system, in part through the release of microbial products. Early-life microbial colonization …

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Tumour-associated macrophages are abundant in many cancers, and often display an
immune-suppressive M2-like phenotype that fosters tumour growth and promotes resistance …

The tumour suppressor gene TP53 is mutated in~ 50% of human cancers. In addition to its
function in tumour suppression, p53 also plays a major role in the response of malignant as …