Neutralizing antibodies (nAbs) are being increasingly used as passive antiviral reagents in
prophylactic and therapeutic modalities and to guide viral vaccine design. In vivo, nAbs can …

Given the absence of an effective vaccine for protection against HIV-1 infection, passive
immunization strategies that utilize potent broadly neutralizing antibodies (bnAbs) to block …

IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and
enhanced effector functions, including highly efficient pathogen neutralisation and …

Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG
important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly …

Soluble angiotensin-converting enzyme 2 (ACE2) constitutes an attractive antiviral capable
of targeting a wide range of coronaviruses using ACE2 as their receptor. Using structure …

Potent neutralizing SARS-CoV-2 antibodies often target the spike protein receptor-binding
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …

Human cytomegalovirus (HCMV) is the most common congenital infection and a leading
cause of stillbirth, neurodevelopmental impairment, and pediatric hearing loss worldwide …

Human cytomegalovirus (HCMV) is the most common vertically transmitted infection
worldwide, yet there are no vaccines or therapeutics to prevent congenital HCMV (cCMV) …

The maternal immune system protects develo** offspring against pathogens before birth
via transplacental transfer and after birth through secreted milk. This transferred maternal …

Humans have four IgG antibody subclasses that selectively or differentially engage immune
effector molecules to protect against infections. Although IgG1 has been studied in detail …