The oral route is by far the most common route of drug administration in the gastrointestinal
tract and can be used for both systemic drug delivery and for treating local gastrointestinal …

Hydrogel is a three-dimensional network polymer material rich in water. It is widely used in
the biomedical field because of its unique physical and chemical properties and good …

There is a clinical need for new, more effective treatments for chronic and debilitating
inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. In this …

Colon targeted drug delivery is an active area of research for local diseases affecting the
colon, as it improves the efficacy of therapeutics and enables localized treatment, which …

The requirement for the favorable therapeutics against ulcerative colitis (UC) is that anti-
inflammatory drugs can be specifically internalized by macrophages and subsequently be …

Aim: To develop novel siRNA delivery system overcoming the limitations of synthetic
nanoparticles, such as potential side effects, nonspecificity and economic production for …

The complex pathogenesis of inflammatory bowel disease (IBD) explains the several
hurdles for finding an efficient approach to cure it. Nowadays, therapeutic protocols aim to …

In plant cells, nanoparticles containing miRNA, bioactive lipids and proteins serve as
extracellular messengers to mediate cell-cell communication in a manner similar to the …

The purpose of this study is to design a cell membrane and mitochondrial targeting
nanoparticle with glutathione stimulus response to deliver procyanidin for effective treatment …

Oxidative stress, resulting from excessive generation of reactive oxygen species (ROS),
plays a pivotal role in the initiation and progression of inflammatory bowel disease (IBD). To …