Leber congenital amaurosis (LCA) is the most severe retinal dystrophy causing blindness or
severe visual impairment before the age of 1 year. Linkage analysis, homozygosity map** …

Postmitotic neurons are produced from a pool of cycling progenitors in an orderly fashion
during development. Studies of cell-fate determination in the vertebrate retina have …

The large number of candidate genes made available by comprehensive genome analysis
requires that relatively rapid techniques for the study of function be developed. Here, we …

The mature mammalian retina is thought to lack regenerative capacity. Here, we report the
identification of a stem cell in the adult mouse eye, which represents a possible substrate for …

We have isolated a novel otx-like homeobox gene, Crx, from the mouse retina. Crx
expression is restricted to develo** and mature photoreceptor cells. CRX bound and …

During the last two to three decades, a large body of work has revealed the molecular basis
of many human disorders, including retinal and vitreoretinal degenerations and …

In the develo** vertebrate retina, diverse neuronal subtypes originate from multipotent
progenitors in a conserved order and are integrated into an intricate laminated architecture …

INTRODUCTION Cone photoreceptors in the human retina enable daytime, color, and high-
acuity vision. The three subtypes of human cones are defined by the visual pigment that they …

Understanding the molecular mechanisms by which distinct cell fate is determined during
organogenesis is a central issue in development and disease. Here, using conditional gene …

During early mouse development the homeobox gene Hesx1 is expressed in prospective
forebrain tissue, but later becomes restricted to Rathke's pouch, the primordium of the …