Psychrophiles thriving permanently at near‐zero temperatures synthesize cold‐active
enzymes to sustain their cell cycle. Genome sequences, proteomic, and transcriptomic …

The discovery of microbial communities in extreme conditions that would seem hostile to life
leads to the question of how the molecules making up these microbes can maintain their …

Protein dynamics have controversially been proposed to be at the heart of enzyme catalysis,
but identification and analysis of dynamical effects in enzyme-catalyzed reactions have …

Atlantis II and Discovery are two hydrothermal and hypersaline deep-sea pools in the Red
Sea rift that are characterized by strong thermohalo-stratification and temperatures steadily …

The role of protein motions in promoting the chemical step of enzyme catalysed reactions
remains a subject of considerable debate. Here, a unified view of the role of protein …

Thermal adaptation of enzymes is essential for both living organism development in extreme
conditions and efficient biocatalytic applications. However, the molecular mechanisms …

Chemical ligation has been used to alter motions in specific regions of dihydrofolate
reductase from E. coli and to investigate the effects of localized motional changes on …

To understand the pressure-adaptation mechanism of deep-sea enzymes, we studied the
effects of pressure on the enzyme activity and structural stability of dihydrofolate reductase …

A key aspect of life's evolution on Earth is the adaptation of proteins to be stable and work in
a very wide range of temperature conditions. A detailed understanding of the associated …

Dihydrofolate reductase has long been used as a model system to study the coupling of
protein motions to enzymatic hydride transfer. By studying environmental effects on hydride …