Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …

Despite advances in treatment, lung cancer survival rates remain low. A better
understanding of the cellular heterogeneity and interplay of cancer-associated fibroblasts …

Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration
correlates with lower patient survival and resistance to therapy. Tumor-associated …

Although heterogeneity of FAP+ Cancer-Associated Fibroblasts (CAF) has been described
in breast cancer, their plasticity and spatial distribution remain poorly understood. Here, we …

Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-
linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma …

The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human
cancer are poorly understood. Here, we show that monocyte subpopulation distribution and …

Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …

Carcinoma-associated fibroblasts (CAF) are key players in the tumor microenvironment.
Here, we characterize four CAF subsets in breast cancer with distinct properties and levels …

The tumor microenvironment (TME) profoundly influences tumorigenesis, with gene
expression in the breast TME capable of predicting clinical outcomes. The TME is complex …