Advances in mammalian cell line development technologies for recombinant protein production
T Lai, Y Yang, SK Ng - Pharmaceuticals, 2013 - mdpi.com
From 2006 to 2011, an average of 15 novel recombinant protein therapeutics have been
approved by US Food and Drug Administration (FDA) annually. In addition, the expiration of …
approved by US Food and Drug Administration (FDA) annually. In addition, the expiration of …
Functional analysis of tight junctions
K Matter, MS Balda - Methods, 2003 - Elsevier
Epithelial and endothelial cells are joined to each other via a set of intercellular junctions
that differ in their morphological appearance, composition, and function. The tight junction or …
that differ in their morphological appearance, composition, and function. The tight junction or …
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
Background Women with HER2–overexpressing breast cancers have poor prognosis, and
many are resistant to the HER2 monoclonal antibody trastuzumab. A subgroup of HER2 …
many are resistant to the HER2 monoclonal antibody trastuzumab. A subgroup of HER2 …
Translation control of the immune checkpoint in cancer and its therapeutic targeting
Cancer cells develop mechanisms to escape immunosurveillance, among which modulating
the expression of immune suppressive messenger RNAs is most well-documented …
the expression of immune suppressive messenger RNAs is most well-documented …
IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector
H Mizuguchi, Z Xu, A Ishii-Watabe, E Uchida… - Molecular Therapy, 2000 - cell.com
The internal ribosome entry site (IRES) has been widely used to coexpress heterologous
gene products by a message from a single promoter. However, little is known about the …
gene products by a message from a single promoter. However, little is known about the …
Activation of the β2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
JA Ballesteros, AD Jensen, G Liapakis… - Journal of Biological …, 2001 - ASBMB
The movements of transmembrane segments (TMs) 3 and 6 at the cytoplasmic side of the
membrane play an important role in the activation of G-protein-coupled receptors. Here we …
membrane play an important role in the activation of G-protein-coupled receptors. Here we …
Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis
Keratins 8 (K8) and 18 (K18) are major components of intermediate filaments (IFs) of simple
epithelial cells and tumors derived from such cells. Structural cell changes during apoptosis …
epithelial cells and tumors derived from such cells. Structural cell changes during apoptosis …
The ZO-1–associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density
Epithelial tight junctions regulate paracellular permeability, restrict apical/basolateral
intramembrane diffusion of lipids, and have been proposed to participate in the control of …
intramembrane diffusion of lipids, and have been proposed to participate in the control of …
Overexpression of the α-2, 6-sialyltransferase in MDCK cells increases influenza virus sensitivity to neuraminidase inhibitors
M Matrosovich, T Matrosovich, J Carr… - Journal of …, 2003 - Am Soc Microbiol
No reliable cell culture assay is currently available for monitoring human influenza virus
sensitivity to neuraminidase inhibitors (NAI). This can be explained by the observation that …
sensitivity to neuraminidase inhibitors (NAI). This can be explained by the observation that …
Development of a stress response therapy targeting aggressive prostate cancer
Oncogenic lesions up-regulate bioenergetically demanding cellular processes, such as
protein synthesis, to drive cancer cell growth and continued proliferation. However, the …
protein synthesis, to drive cancer cell growth and continued proliferation. However, the …