Tumor microenvironment targeted nanotherapeutics for cancer therapy and diagnosis: A review
S Thakkar, D Sharma, K Kalia, RK Tekade - Acta biomaterialia, 2020 - Elsevier
Recent findings suggest that the cellular and extracellular materials surrounding the
cancerous cells from an atypical tumor microenvironment (TM) play a pivotal role in the …
cancerous cells from an atypical tumor microenvironment (TM) play a pivotal role in the …
The Warburg effect and glucose-derived cancer theranostics
RK Tekade, X Sun - Drug Discovery Today, 2017 - Elsevier
Highlights•Tumor cells increase their metabolic rates as well as glucose uptake to maintain
amplified proliferation,•Consequently, tumor cells switch from mitochondrial oxidative …
amplified proliferation,•Consequently, tumor cells switch from mitochondrial oxidative …
Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route
Background: Most of the active pharmaceutical ingredients discovered recently in
pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral …
pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral …
Augmented delivery of gemcitabine in lung cancer cells exploring mannose anchored solid lipid nanoparticles
Gemcitabine (GmcH) is an effective anti-cancer agent used in the chemotherapy of lung
cancer. However, the clinical applications of GmcH has been impeded primarily due to its …
cancer. However, the clinical applications of GmcH has been impeded primarily due to its …
Dendrimer, liposomes, carbon nanotubes and PLGA nanoparticles: one platform assessment of drug delivery potential
Abstract Liposomes (LIP), nanoparticles (NP), dendrimers (DEN), and carbon nanotubes
(CNTs), represent eminent classes of drug delivery devices. A study was carried out …
(CNTs), represent eminent classes of drug delivery devices. A study was carried out …
Development of metronidazole loaded chitosan nanoparticles using QbD approach—A novel and potential antibacterial formulation
The aim of this study was to design, optimize, and develop metronidazole (Met) loaded
nanoparticles (MetNp) by employing quality-based design (QbD) as well as a risk …
nanoparticles (MetNp) by employing quality-based design (QbD) as well as a risk …
Impact of pegylation on biopharmaceutical properties of dendrimers
S Thakur, P Kesharwani, RK Tekade, NK Jain - Polymer, 2015 - Elsevier
In the recent years, conjugation of polyethylene glycol (PEG) on dendrimer has become an
established and highly refined technology for delivery of bioactives. Dendrimers provide an …
established and highly refined technology for delivery of bioactives. Dendrimers provide an …
Nanotechnology for the development of nanomedicine
A technology of 21 st century, nanotechnology has the potential to transform almost every
area of applications right from making a needle to robot. It is basically involves manipulating …
area of applications right from making a needle to robot. It is basically involves manipulating …
RNAi-combined nano-chemotherapeutics to tackle resistant tumors
RK Tekade, M Tekade, P Kesharwani… - Drug discovery today, 2016 - Elsevier
Highlights•Nanotechnology can protect siRNA against RNAse degradation.•siRNA adopts
an alternative pathway to knock genes with high specificity to cure cancer.•An ideal vector is …
an alternative pathway to knock genes with high specificity to cure cancer.•An ideal vector is …
Lyophilized mucoadhesive-dendrimer enclosed matrix tablet for extended oral delivery of albendazole
S Mansuri, P Kesharwani, RK Tekade… - European Journal of …, 2016 - Elsevier
Dendrimers are multifunctional carriers widely employed for delivering drugs in a variety of
disease conditions including HIV/AIDS and cancer. Albendazole (ABZ) is a commonly used …
disease conditions including HIV/AIDS and cancer. Albendazole (ABZ) is a commonly used …