Immune reactions to small molecular compounds, such as drugs, can cause a variety of
diseases involving the skin, liver, kidney, and lungs. In many drug hypersensitivity reactions …

Toxic epidermal necrolysis is a life-threatening, typically drug-induced mucocutaneous
disease. It is clinically characterized as a widespread sloughing of the skin and mucosa …

Background The use of abacavir a potent HIV—1 nucleosideanalogue reverse—
transcriptase inhibitor is complicated by a potentially life-threatening hypersensitivity …

The normal metabolism of drugs can generate metabolites that have intrinsic chemical
reactivity towards cellular molecules, and therefore have the potential to alter biological …

Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients;
they also markedly increase the uncertainty of drug development. The major targets are skin …

Susceptibility to a clinically significant drug hypersensitivity syndrome associated with
abacavir use seems to have a strong genetic component. We have previously shown that …

BACKGROUND: Toxic epidermal necrolysis (TEN) is a very rare but extremely severe drug
reaction characterized by widespread apoptosis of epidermis with extensive blisters. We …

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe
cutaneous adverse drug reactions, which can be caused by a certain number of specific …

Drug-induced liver injury (DILI) has become a major topic in the field of Hepatology and
Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic …

Acute generalized exanthematous pustulosis (AGEP) is an uncommon eruption most often
provoked by drugs, by acute infections with enteroviruses, or by mercury. It is characterized …