The gasdermins are a family of recently identified pore-forming effector proteins that cause
membrane permeabilization and pyroptosis, a lytic pro-inflammatory type of cell death …

Several new discoveries have revived interest in the pathogenic potential and possible
clinical roles of IL-18. IL-18 is an IL-1 family cytokine with potent ability to induce IFNγ …

As organelles of the innate immune system, inflammasomes activate caspase-1 and other
inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive …

Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require
cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and …

Pyroptosis, an inflammatory programmed cell death process, has recently garnered
significant attention due to its pivotal role in various neurological diseases. This review …

Interleukin (IL)-18 and IL-1β are potent pro-inflammatory cytokines that contribute to
inflammatory conditions such as rheumatoid arthritis and Alzheimer's disease. They are …

The NLRP3 inflammasome is a multiprotein complex that regulates caspase‐1 activation
and subsequent interleukin (IL)‐1β and IL‐18 release from innate immune cells in response …

A major pathway for proinflammatory protein release by macrophages is inflammasome-
mediated pyroptotic cell death. As conventional secretion, unconventional secretion, and …

Dopamine dysregulation in schizophrenia may be associated with midbrain inflammation.
Previously, we found elevated levels of pro-inflammatory cytokine mRNAs in the post …

Proteins are secreted from eukaryotic cells by several mechanisms besides the well-
characterized classical secretory system. Proteins destined to enter the classical secretory …