Transgenerational epigenetic inheritance: myths and mechanisms
Since the human genome was sequenced, the term" epigenetics" is increasingly being
associated with the hope that we are more than just the sum of our genes. Might what we …
associated with the hope that we are more than just the sum of our genes. Might what we …
TET enzymes, TDG and the dynamics of DNA demethylation
DNA methylation has a profound impact on genome stability, transcription and development.
Although enzymes that catalyse DNA methylation have been well characterized, those that …
Although enzymes that catalyse DNA methylation have been well characterized, those that …
[HTML][HTML] SOX17 is a critical specifier of human primordial germ cell fate
Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state.
However, without a tractable experimental model, the mechanism of human PGC (hPGC) …
However, without a tractable experimental model, the mechanism of human PGC (hPGC) …
The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells
Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …
DNA elements, regulating transcription and establishing cellular identity. The recent …
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development
R Yan, X Cheng, C Gu, Y Xu, X Long, J Zhai, F Sun… - Nature Genetics, 2023 - nature.com
Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …
Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine
Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-
wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that …
wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that …
[HTML][HTML] Pathogenesis of endometriosis: the genetic/epigenetic theory
PR Koninckx, A Ussia, L Adamyan, A Wattiez… - Fertility and sterility, 2019 - Elsevier
Objective To study the pathophysiology of endometriosis. Design Overview of observations
on endometriosis. Setting Not applicable. Patient (s) None. Interventions (s) None. Main …
on endometriosis. Setting Not applicable. Patient (s) None. Interventions (s) None. Main …
Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development
V Ashapkin, A Suvorov, JR Pilsner… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …
by delayed parenthood. Older gametes are generally less fertile, accumulating and …
Specification and epigenetic programming of the human germ line
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …