With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

Hydrogen bonding is responsible for the structure of much of the world around us. The
unusual and complex properties of bulk water, the ability of proteins to fold into stable three …

Transient delivery of CRISPR‐based genome editing effectors is important to reduce off‐
target effects and immune responses. Recently extracellular vesicles (EVs) have been …

With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

Membraneless compartments, such as complex coacervates, have been hypothesized as
plausible prebiotic micro-compartments due to their ability to sequester RNA; however, their …

CRISPR/Cas9 uses a guide RNA (gRNA) molecule to execute sequence‐specific DNA
cleavage and it has been widely used for genome editing in many organisms. Modifications …

Using the atomic structures of the large ribosomal subunit from Haloarcula marismortui and
its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and …

RNA molecules adopt specific three-dimensional structures critical to their function. Many
essential metabolic processes, including protein synthesis and RNA splicing, are carried out …

Although RNA is generally thought to be a passive genetic blueprint, some RNA molecules,
called ribozymes, have intrinsic enzyme-like activity—they can catalyse chemical reactions …

Activation-induced cytidine deaminase (AID) plays an essential role in class switch
recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes. We …