Zika virus

S Masmejan, D Musso, M Vouga, L Pomar… - Pathogens, 2020 - mdpi.com
Zika virus (ZIKV), a neurotropic single-stranded RNA flavivirus, remains an important cause
of congenital infection, fetal microcephaly, and Guillain-Barré syndrome in populations …

Updates on dengue vaccine and antiviral: where are we heading?

H Norshidah, R Vignesh, NS Lai - Molecules, 2021 - mdpi.com
Approximately 100–400 million people from more than 100 countries in the tropical and
subtropical world are affected by dengue infections. Recent scientific breakthroughs have …

Prior Dengue virus exposure shapes T cell immunity to Zika virus in humans

A Grifoni, J Pham, J Sidney, PH O'Rourke… - Journal of …, 2017 - Am Soc Microbiol
While progress has been made in characterizing humoral immunity to Zika virus (ZIKV) in
humans, little is known regarding the corresponding T cell responses to ZIKV. Here, we …

Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge

J Wen, A Elong Ngono, JA Regla-Nava, K Kim… - Nature …, 2017 - nature.com
Zika virus (ZIKV) and dengue virus (DENV) are antigenically related flaviviruses that share
cross-reactivity in antibody and T cell responses, and co-circulate in increasing numbers of …

Innate and adaptive immune evasion by dengue virus

MF Lee, GZ Voon, HX Lim, ML Chua… - Frontiers in Cellular and …, 2022 - frontiersin.org
Dengue is a mosquito-borne disease which causes significant public health concerns in
tropical and subtropical countries. Dengue virus (DENV) has evolved various strategies to …

Immune-mediated pathogenesis in dengue virus infection

A Khanam, H Gutiérrez-Barbosa, KE Lyke, JV Chua - Viruses, 2022 - mdpi.com
Dengue virus (DENV) infection is one of the major public health concerns around the globe,
especially in the tropical regions of the world that contribute to 75% percent of dengue …

Critical role of CD4+ T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection

CGO Lucas, JZ Kitoko, FM Ferreira, VG Suzart… - Nature …, 2018 - nature.com
Protective adaptive immunity to Zika virus (ZIKV) has been mainly attributed to cytotoxic
CD8+ T cells and neutralizing antibodies, while the participation of CD4+ T cells in …

Zika vaccines and therapeutics: landscape analysis and challenges ahead

A Wilder-Smith, K Vannice, A Durbin, J Hombach… - BMC medicine, 2018 - Springer
Abstract Background Various Zika virus (ZIKV) vaccine candidates are currently in
development. Nevertheless, unique challenges in clinical development and regulatory …

Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas

A Grifoni, MA Angelo, B Lopez, PH O'Rourke… - Frontiers in …, 2017 - frontiersin.org
Background Dengue is a major public health problem worldwide. Assessment of adaptive
immunity is important to understanding immunopathology and to define correlates of …

[HTML][HTML] Current understanding of the role of T cells in chikungunya, dengue and zika infections

M Mapalagamage, D Weiskopf, A Sette, AD De Silva - Viruses, 2022 - mdpi.com
Arboviral infections such as Chikungunya (CHIKV), Dengue (DENV) and Zika (ZIKV) are a
major disease burden in tropical and sub-tropical countries, and there are no effective …